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Submarine slope failures pose risks to coastlines because they can damage infrastructure and generate tsunamis. Passive margin slope failures represent the largest mass failures on Earth, yet we know little about their dynamics. While numerous studies characterize the lithology, structure, seismic attributes and geometry of failure deposits, we lack direct observations of failure evolution. Thus, we lack insight into the relationships between initial conditions, slope failure initiation and evolution, and final deposits. To investigate submarine slope failure dynamics in relation to initial conditions and to observe failure processes we performed physical experiments in a benchtop flume and produced numerical models. Submarine slope failures were induced under controlled pore pressure within sand–clay mixtures (0–5 wt% clay). Increased clay content corresponded to increased cohesion and pore pressure required for failure. Subsurface fractures and tensile cracks were only generated in experiments containing clay. Falling head tests showed a log-linear relation between hydraulic conductivity and clay content, which we used in our numerical models. Models of our experiments effectively simulate overpressure (pressure in excess of hydrostatic) and failure potential for (non)cohesive sediment mixtures. Overall our work shows the importance of clay in reducing permeability and increasing cohesion to create different failure modes due to overpressure.